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| Numerical simulations of the targeted delivery of the inhalable drug in pulmonary airway of a COVID-19 patient |
| Received:February 05, 2021 Revised:September 21, 2021 |
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| DOI：10.7511/jslx20210205001 |
| KeyWord:COVID-19 numerical simulation airway droplet aerosol dynamics |
| Author | Institution |
| 丁婷 |
南京师范大学 能源与机械工程学院, 南京 |
| 张亚 |
西安交通大学 医学院第二附属医院耳鼻咽喉头颈外科, 西安 |
| 陈晓乐 |
南京师范大学 能源与机械工程学院, 南京 |
| 解晓健 |
南京师范大学 能源与机械工程学院, 南京 |
| 杨敏娟 |
西安交通大学 医学院第二附属医院耳鼻咽喉头颈外科, 西安 |
| 夏学鹰 |
南京师范大学 能源与机械工程学院, 南京 |
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| Abstract: |
| The COVID-19 has spread throughout the world.The number of COVID-19 patients still increase rapidly worldwide.The treatment of the COVID-19 patients attracts attention of the researchers.Diagnosis and Treatment Protocol for COVID-19 indicates that atomization inhalation of Alpha-interferon could be used for the antiviral therapy.To explore the possible method for enhancing the effectiveness of the inhalation treatment,numerical simulation was applied to analyze the treatment of a patient with moderate COVID-19 symptoms.Based on the spiral CT scan images on admission,we analyzed the severity of the lung segments.The geometry of the lung was reconstructed according to the lung segmentations.Drug delivery simulations for droplets with different diameters were carried out at low inhalation flow rate (15 L/min).The numbers of the droplets deposited in the airway those delivered into the deeper lung regions were recorded.The relationship between the initial locations of the droplets and their final destinations were obtained.The results indicate that the overall deep lung delivery efficiency of the droplets decreases with the increase of the Stokes number.The delivery efficiency could be significantly increased,if the droplets could be released from two circular areas at the inlet.This investigation proves that the targeted delivery of the inhalable drug is possible. |