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| Numerical simulation of intimal thickening in a bifurcating artery |
| Revised:September 23, 2005 |
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| DOI：10.7511/jslx20075117 |
| KeyWord:intimal thickening,wall shear stress,cell-filled method,carotid bifurcation,atherosclerosis |
| JIANG Wen-tao FAN Yu-bo ZOU Yuan-wen LI Jin-chuan CHEN Jun-kai |
| 1.Biomechanical Engineering Laboratory,Sichuan University,Chengdu 610065,China;2.Department of Bioengineering,Beihang University,Beijing 100083,China |
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| Abstract: |
| Intimal thickening is a complicated process from plaque formation to artery-obstructed.In this process,intimal thickening,the change of artery geometry and hemo-dynamics are interacted.A new numerical skill named "Cell-filled method" is applied to simulate the process of intimal thickening in a carotid bifurcation under critical low wall shear stress condition.The new method can overcome the limitation of previous methods,such as the discontinuous of simulation and the trouble of model re-meshing.Results showed that the artery can't be obstructed if the low wall shear stress was chosen as the criterion of intimal thickening,but the interaction among intimal thickening,the change of artery geometry and hemo-dynamics is notable and can be simulated numerically.It was observed numerically that the process of intimal thickening includes two stages of "thickening" and "spreading".The most severe stenosis,which straitness ratio is 34.4%,occurs at the outside wall of sinus and at a distance of 5mm from bifurcation section.The location of intimal thickening and plaque shape are agreed with clinical observation. |
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