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| A numerical study on low density lipoprotein transport in arterial stenoses: LDL concentration polarization |
| Revised:January 07, 2002 |
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| DOI：10.7511/jslx20023056 |
| KeyWord:mass transport,concentration polarization,wall shear rate,atherosclerosis |
| Deng Xiaoyan |
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| Abstract: |
| The transport of atherogenic lipids (LDL) in an arterial stenosis with a semi-permeable wall is simulated numerically. The numerical analysis predicts that in the presence of filtration flow across the arterial wall, the lipids are accumulated at the blood/arterial wall interface, with the highest concentration occurring at the flow separation point right distal to the summit of the stenosis. The analysis also predicts a gradual decrease in the peak value of lipid concentration with increasing Reynolds number and severity of stenosis. The fluid layer with highly concentrated lipids in the area of flow separation point may play an important role in the localization of atherosclerosis and be responsible for the formation and development of the arterial stenosis. |
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