| 邓小燕.动脉狭窄内低密度脂蛋白传输的数值研究：LDL的浓度极化现象[J].计算力学学报,2002,19(3):253~259 |
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| 动脉狭窄内低密度脂蛋白传输的数值研究：LDL的浓度极化现象 |
| A numerical study on low density lipoprotein transport in arterial stenoses: LDL concentration polarization |
| 修订日期：2002-01-07 |
| DOI：10.7511/jslx20023056 |
| 中文关键词: 质量传输,浓度极化,壁面剪切率,动脉粥样硬化 |
| 英文关键词:mass transport,concentration polarization,wall shear rate,atherosclerosis |
| 基金项目:国家自然科学基金 ( 10 172 0 2 7)，美国 WhitakerFoundation( 97-0 2 84)资助项目 |
| 邓小燕 |
| 大连理工大学工业装备结构分析国家重点实验室 大连116024 |
| 摘要点击次数: 1570 |
| 全文下载次数: 19 |
| 中文摘要: |
| 用计算机数值模拟的方法 ,对低密度脂蛋白 ( LDL)在动脉狭窄血管段内的质量传输进行了研究。计算结果表明 ,由于血管壁渗流的存在 ,LDL这样的脂质大分子会聚积在血管的内壁表面 ,发生一种工程上称为浓度极化的现象。LDL浓度在动脉狭窄口后的流动分离点出现峰值。该浓度峰值随雷诺数和动脉狭窄度的增加而呈逐渐下降的趋势。作者认为 ,该区域 LDL浓度的局部升高是引发动脉粥样硬化局部性和动脉狭窄产生的一个非常重要的原因。 |
| 英文摘要: |
| The transport of atherogenic lipids (LDL) in an arterial stenosis with a semi-permeable wall is simulated numerically. The numerical analysis predicts that in the presence of filtration flow across the arterial wall, the lipids are accumulated at the blood/arterial wall interface, with the highest concentration occurring at the flow separation point right distal to the summit of the stenosis. The analysis also predicts a gradual decrease in the peak value of lipid concentration with increasing Reynolds number and severity of stenosis. The fluid layer with highly concentrated lipids in the area of flow separation point may play an important role in the localization of atherosclerosis and be responsible for the formation and development of the arterial stenosis. |
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